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Int J Sports Med 2012; 33(05): 402-409
DOI: 10.1055/s-0032-1301888
Immunology
© Georg Thieme Verlag KG Stuttgart · New York

Exercise Inhibits Allergic Lung Inflammation

A.C. D. Silva
1   Physical Therapy, University of São Paulo, Sao Paulo, Brazil
,
R. P. Vieira
2   Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Säo Paulo, SP, Brazil
,
M. Nisiyama
1   Physical Therapy, University of São Paulo, Sao Paulo, Brazil
,
A.B. G. Santos
3   Pathology (LIM 05), University of Sao Paulo, Sao Paulo, Brazil
,
A. Perini
4   Clinical Medicine (LIM 20), University of Sao Paulo, Sao Paulo, Brazil
,
T. Mauad
3   Pathology (LIM 05), University of Sao Paulo, Sao Paulo, Brazil
,
M. Dolhnikoff
5   School of Medicine, Pathology, Sao Paulo University, Sao Paulo, Brazil
,
M. A. Martins
4   Clinical Medicine (LIM 20), University of Sao Paulo, Sao Paulo, Brazil
,
C. R. Carvalho
1   Physical Therapy, University of São Paulo, Sao Paulo, Brazil
› Author Affiliations
Further Information

Publication History



accepted after revision 28 December 2011

Publication Date:
17 April 2012 (online)

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Abstract

Aerobic conditioning (AC) performed either during or after sensitization reduces allergic inflammation in mice; however, the effects of AC performed before and during allergic sensitization on airway inflammation are unknown. Mice were divided into Control, AC, OVA, and AC + OVA groups. Mice were trained in a treadmill followed by either ovalbumin (OVA) sensitization or saline administration. Peribronchial inflammation, OVA-specific IgE and IgG1 titers, the expression of Th1 and Th2 cytokines, and airway remodeling were evaluated, as well as the expression of Eotaxin, RANTES, ICAM-1, VCAM-1, TGF-β and VEGF. Aerobic conditioning performed before and during allergic sensitization displayed an inhibitory effect on the OVA-induced migration of eosinophils and lymphocytes to the airways, a reduction of IgE and IgG1 titers and an inhibition of the expression of Th2 cytokines. The AC + OVA group also demonstrated reduced expression of ICAM-1, VCAM-1, RANTES, TGF-β and VEGF, as well as decreased airway remodeling (p<0.05). The effects of AC before and during the sensitization process inhibit allergic airway inflammation and reduce the production of Th2 cytokines and allergen-specific IgE and IgG1.

Key words

asthma - cytokines - lungs - aerobic conditioning - adhesion molecules - growth factors
 

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