Synthesis 2013; 45(3): 330-333
DOI: 10.1055/s-0032-1317847
short paper
© Georg Thieme Verlag Stuttgart · New York

New, Efficient Approach for the Ligand-Free Suzuki–Miyaura Reaction of 5-Iodo-2′-deoxyuridine in Water

Guillaume Sartori
Transformations Intégrées de la Matière Renouvelable, UTC-ESCOM, Centre de recherche Royallieu, BP 20529, 60205 Compiègne, France   Fax: +33(3)44971591   Email: christophe.len@utc.fr
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Gwénaëlle Hervé
Transformations Intégrées de la Matière Renouvelable, UTC-ESCOM, Centre de recherche Royallieu, BP 20529, 60205 Compiègne, France   Fax: +33(3)44971591   Email: christophe.len@utc.fr
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Gérald Enderlin
Transformations Intégrées de la Matière Renouvelable, UTC-ESCOM, Centre de recherche Royallieu, BP 20529, 60205 Compiègne, France   Fax: +33(3)44971591   Email: christophe.len@utc.fr
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Christophe Len*
Transformations Intégrées de la Matière Renouvelable, UTC-ESCOM, Centre de recherche Royallieu, BP 20529, 60205 Compiègne, France   Fax: +33(3)44971591   Email: christophe.len@utc.fr
› Author Affiliations
Further Information

Publication History

Received: 14 October 2012

Accepted after revision: 19 November 2012

Publication Date:
04 January 2013 (online)


Abstract

A series of 5-aryl-2′-deoxyuridines was prepared, using ligandless Suzuki–Miyaura cross-coupling reactions in neat water, starting from 5-iodo-2′-deoxyuridine as totally deprotected starting material. This ligand-free process gave good to high isolated yields within short reaction times and with low loadings of palladium.