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Synthesis 2013; 45(22): 3099-3102
DOI: 10.1055/s-0033-1338520
DOI: 10.1055/s-0033-1338520
practical synthetic procedures
Substituted 2,2′-Bipyridines by Nickel Catalysis: 4,4′-Di-tert-butyl-2,2′-bipyridine
Further Information
Publication History
Received: 14 June 2013
Accepted after revision: 17 July 2013
Publication Date:
15 August 2013 (online)
Abstract
A simple, ligand-free synthesis of the important bipyridyl ligand 4,4′-di-tert-butyl-2,2′-bipyridine is presented. 5,5′-Bis(trifluoromethyl)-2,2′-bipyridine is also synthesized by the same protocol. The syntheses efficiently couple the parent 2-chloropyridines by a nickel-catalyzed dimerization with manganese powder as the terminal reductant.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
Primary Data
- for this article are available online at http://www.thieme-connect.com/ejournals/toc/synthesis and can be cited using the following DOI: 10.4125/pd0049th.
- Primary Data
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Selected examples: