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Synthesis 2013; 45(14): 1991-1996
DOI: 10.1055/s-0033-1338799
DOI: 10.1055/s-0033-1338799
paper
Total Synthesis of (+)-Pinellic Acid
Further Information
Publication History
Received: 08 March 2013
Accepted after revision: 18 April 2013
Publication Date:
17 May 2013 (online)
Abstract
A straightforward strategy for the synthesis of (+)-pinellic acid in 16% overall yield and 13 steps, starting from (1R)-1-(furan-2-yl)hexan-1-ol, is described. Key reactions in the synthesis include a Sharpless kinetic resolution, oxidation of a protected furan to reveal a but-2-ene-1,4-dione moiety, and an asymmetric reduction.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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