Highly Regioselective Allylic Substitution Reactions Catalyzed by an Air-Stable (π-Allyl)iridium Complex Derived from Dinaphthocyclooctatetraene and a Phosphoramidite Ligand

Abstract

An air-stable (π-allyl)iridium complex derived from dinaphthocyclooctatetraene and a phosphoramidite ligand has been synthesized and found to be highly efficient in iridium-catalyzed allylic substitution reactions. This catalyst features excellent regioselectivity and high stability. When NaCH(CO₂Me)₂ was used as the nucleophile, the catalyst loading in allylic alkylation reactions can be as low as 0.01 mol%.

Key words

(π-allyl)iridium complex - allylic substitution - enantio­selectivity - regioselectivity - dinaphthocyclooctatetraene

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