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Synthesis 2014; 46(01): 49-56
DOI: 10.1055/s-0033-1340051
DOI: 10.1055/s-0033-1340051
paper
Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a One-Pot Ugi-Azide/Pictet–Spengler Process
Further Information
Publication History
Received: 11 July 2013
Accepted after revision: 03 October 2013
Publication Date:
23 October 2013 (online)
Abstract
A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet–Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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