Synthesis 2014; 46(01): 110-118
DOI: 10.1055/s-0033-1340083
paper
© Georg Thieme Verlag Stuttgart · New York

Studies toward the Synthesis of Iejimalides A–D: Preparation of the C3–11 and C12–C24 Fragments

Gowravaram Sabitha*
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: gowravaramsr@yahoo.com   Email: sabitha@iict.res.in
,
Ch. Gurumurthy
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: gowravaramsr@yahoo.com   Email: sabitha@iict.res.in
,
Jhillu Singh Yadav
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: gowravaramsr@yahoo.com   Email: sabitha@iict.res.in
› Author Affiliations
Further Information

Publication History

Received: 30 July 2013

Accepted after revision: 10 October 2013

Publication Date:
07 November 2013 (online)


Abstract

The convergent synthesis of the C3–C11 and C12–C24 fragments of the iejimalides A–D is described. The C3–C11 fragment is obtained by a cross-metathesis reaction, while the C12–C24 fragment is derived from a Still–Gennari modified Horner–Wadsworth­–Emmons olefination.

Supporting Information