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Synthesis 2014; 46(02): 230-234
DOI: 10.1055/s-0033-1340142
DOI: 10.1055/s-0033-1340142
paper
Solvent-Free, Base-Free Microwave-Mediated Iridium-Catalyzed N-Alkylation of Amides with Alcohols
Further Information
Publication History
Received: 20 September 2013
Accepted: 17 October 2013
Publication Date:
22 November 2013 (online)
Abstract
Solvent-free, base-free microwave-mediated (Cp*IrCl2)2-catalyzed conditions for the N-alkylation of amides with alcohols have been developed. A series of primary and secondary alcohols have been shown to produce high yields of N-alkyl arylamides and N-alkyl alkylamides.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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