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Synthesis 2014; 46(08): 1046-1051
DOI: 10.1055/s-0033-1340820
DOI: 10.1055/s-0033-1340820
practical synthetic procedures
A Simple and Convenient Method for the Synthesis of N,N-Diaryl Tertiary Amines
Further Information
Publication History
Received: 27 December 2013
Accepted after revision: 22 January 2014
Publication Date:
25 February 2014 (online)
Abstract
Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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