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Endoscopy 2013; 45(12): 992-996
DOI: 10.1055/s-0033-1344862
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Long-term outcome of endoscopic resection of superficial adenocarcinoma of the esophagogastric junction

Masayoshi Yamada
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Ichiro Oda
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Satoru Nonaka
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Haruhisha Suzuki
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Shigetaka Yoshinaga
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Hirokazu Taniguchi
2   Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
,
Shigeki Sekine
3   Molecular Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
,
Ryoji Kushima
2   Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
,
Yutaka Saito
1   Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Takuji Gotoda
4   Department of Gastroenterology, Tokyo Medical University, Tokyo Japan
› Author Affiliations
Further Information

Publication History

submitted 07 February 2013

accepted after revision 15 July 2013

Publication Date:
28 November 2013 (online)

Also available at
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Background and study aim: Endoscopic resection has been favored for the management of intramucosal adenocarcinoma of the esophagogastric junction (AEGJ) over standard treatment with surgical resection. Several previous studies have reported only short-term outcomes. The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ.

Patients and methods: A retrospective cohort study included 53 consecutive patients with superficial AEGJ who underwent ESD between 2001 and 2007 at the National Cancer Center Hospital, Tokyo, Japan. Rates of overall survival, recurrence-free survival, and cause-specific survival of patients with AEGJ after endoscopic resection were analyzed.

Results: The 5-year overall, recurrence-free, and cause-specific survival rates in the 53 patients were 94.2 %, 92.3 % and 96.1 %, respectively. The median follow-up was 6.1 years. En bloc, R0, and curative resection rates were 100 %, 79 %, 68 %, respectively. In 36 patients with curative resection, the cause-specific survival rate was 100 % and no recurrence or metastases were detected. In 17 patients with non-curative resection, recurrence was found in three patients (17 %); two of the three patients died of their disease whilst one patient received chemotherapy.

Conclusions: Superficial AEGJ can be well controlled by ESD when curative resection is achieved.

 

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