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Drug Res (Stuttg) 2014; 64(05): 240-245
DOI: 10.1055/s-0033-1357127
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives

A. Bansal
1   Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
,
P. Kumar
1   Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
,
B. Narasimhan
1   Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
› Author Affiliations
Further Information

Publication History

received 11 August 2013

accepted 07 September 2013

Publication Date:
08 October 2013 (online)

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Abstract

A series of 2-hydroxypropanoic acid derivatives (1–26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier’s valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.

Key words

antibacterial - antifungal - synthesis - QSAR
 

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