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Synthesis 2014; 46(22): 3059-3066
DOI: 10.1055/s-0034-1378541
DOI: 10.1055/s-0034-1378541
paper
A Novel N-Benzylation of Phenothiazine with Benzyl Alcohols Activated by n-Propylphosphonic Acid Anhydride (T3P®)
Further Information
Publication History
Received: 11 June 2014
Accepted after revision: 28 June 2014
Publication Date:
13 August 2014 (online)
Abstract
Phenothiazine readily undergoes N-benzylation with benzyl alcohols by in situ activation with T3P® (propylphosphonic acid anhydride) in a straightforward fashion and with good to excellent yields.
Key words
alcohol activation - benzyl alcohols - nucleophilic substitution - phenothiazine - tertiary amineSupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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For reviews on nucleophilic substitutions, see e.g.: