Total Synthesis of Atisane-Type Diterpenoids and Related Diterpenoid Alkaloids

Abstract

Atisane-type compounds and related natural products are attractive for their molecular skeletons and pharmaceutical bioactivities. This review summarizes total syntheses of atisane-type diterpenoids and related diterpenoid alkaloids.

1 Introduction

2 Total Synthesis and Synthetic Studies of Atisane-Type Diterpenoids and Related Diterpenoid Alkaloids

2.1 Ionic Methods

2.1.1 S_N2 Substitution Reaction

2.1.2 Aldol Reaction

2.1.3 Intramolecular Double Michael Addition

2.2 Free-Radical Methods

2.2.1 Free-Radical Rearrangement

2.2.2 Free-Radical Addition

2.3 Diels–Alder Cycloaddition

3 Conclusion

Key words

atisane - diterpenoids - alkaloids - total synthesis - bicyclo[2.2.2]octane

• References

• 1 G.-L. Zhu and R. Liu contributed equally to this review.
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