Hydroaminoalkylation: Early-Transition-Metal-Catalyzed α-Alkylation of Amines

Abstract

The recent development and progress of early-transition-metal-catalyzed C–H alkylation adjacent to nitrogen of unprotected amines with alkenes are summarized. Group 4 and 5 metal complexes are very effective for hydroaminoalkylation catalysis, an emerging atom-economic C(sp³)–C(sp³) bond formation strategy.

1 Introduction

2 Group 4 Hydroaminoalkylation Catalysis

2.1 Intramolecular Hydroaminoalkylation

2.2 Intermolecular Hydroaminoalkylation

3 Group 5 Hydroaminoalkylation Catalysis

4 Conclusions and Outlook

Key words

early transition metals - metallaziridine - amines - alkenes - C–H alkylation

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