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Synthesis 2015; 47(09): 1337-1347
DOI: 10.1055/s-0034-1379894
DOI: 10.1055/s-0034-1379894
paper
Diversely Substituted Indoloazepinones and Indoloazocinones: A Post-Ugi Gold-Catalyzed Regioselective Carbocyclization Approach
Further Information
Publication History
Received: 27 October 2014
Accepted after revision: 15 January 2015
Publication Date:
26 February 2015 (online)
Abstract
A post-Ugi gold-catalyzed regioselective intramolecular carbocyclization strategy is reported. A better cationic gold system, compared to our previous report, has been optimized and utilized. The method presented exhibits excellent functional group compatibility including bulky substitutions on alkynes and allows the direct access to indoloazepinones and indoloazocinones in good to excellent yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379894.
- Supporting Information
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For the synthesis of indoloazepines using isonitrile based multicomponent reaction, see:
For the synthesis of indoloazocines using isonitrile based multicomponent reaction, see: