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Synthesis 2015; 47(05): 726-736
DOI: 10.1055/s-0034-1379975
DOI: 10.1055/s-0034-1379975
paper
Copper-Catalyzed One-Pot Synthesis of α-Ketoamides from 1-Arylethanols
Weitere Informationen
Publikationsverlauf
Received: 14. November 2014
Accepted after revision: 15. Dezember 2014
Publikationsdatum:
28. Januar 2015 (online)
Abstract
A copper-catalyzed one-pot strategy for the synthesis of α-ketoamides from 1-arylethanols is described. This triple oxidation of 1-arylethanols involves alcohol oxidation, sp3 C–H oxidation, and oxidative amidation with amines. The protocol is highly efficient, delivering α-ketoamides in good to excellent yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379975.
- Supporting Information
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