PDF herunterladen
Horm Metab Res 2015; 47(04): 284-288
DOI: 10.1055/s-0034-1395607
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

The Relation of Preeclampsia and Serum Level of 25-Hydroxyvitamin D in Mothers and Their Neonates: A Case Control Study in Iran

Z. Mohaghegh
1   Family Health, Health Deputy of Medical University of Yasuj, Yasuj, Iran
,
P. Abedi
2   Midwifery Department, Reproductive Health Promotion Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
,
T. Dilgouni
3   Midwifery Department, The International University of Shahid Beheshti Medical University, Tehran, Iran
,
F. Namvar
4   Institute of Tropical Forestry and Forest Products (INTROP), University Putra Malaysia, UPM Serdang, Selangor, Malaysia
5   Department of Medicine, Applied Biology Research Center, Mashhad Branch, Islamic Azad University, Mashhad, Iran
,
S. Ruzafza
6   Midwifery Department, Yasuj Medical University of Medical Sciences, Yasuj, Iran
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 23. Juni 2014

accepted after second 03. November 2014

Publikationsdatum:
22. Januar 2015 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Abstract

The predisposing factors of preeclampsia may endanger the mother’s heath as well as her neonate. One hypothesis related to preeclampsia is vitamin D deficiency or insufficiency. This study was conducted to evaluate the relationship between preeclampsia and the serum level of 25-hydroxyvitamin D (25-OH-D) in mothers and their neonates. In this case-control study, we recruited 41 preeclamptic and 50 healthy women from the Imam Khomeini Hospital in Ahvaz, Iran. Venous blood (2 ml) from mothers (in time of labor) and 2 ml of blood from the umbilical cord were taken, centrifuged, stored at −30°C and sent to a laboratory for analysis of 25-OH-D by ELISA. Vitamin D levels<20 ng/ml were regarded as deficiency, levels between 21–29 ng/ml were regarded as insufficiency, and if levels were higher than 30 ng/ml, these were considered normal. Independent t-test, chi-square, Spearman correlation coefficient and logistic regression were used to analyze data. Mean levels of 25-OH-D were significantly lower in preeclamptic women (15.2±13.6 vs. 23.3±15.3 ng/ml, p=0.001) and in their neonates (15.2±13.1 vs. 21.6±12.6 ng/ml, p=0.01) compared to normal pregnant women and their neonates. There was a significant relationship between the levels of vitamin D in preeclamptic women with levels of this vitamin in their neonates (r=0.901, p=0.0001). 25-OH-D deficiency that exist in preeclamptic mothers, may be a health risk for their infants, therefore, early use of vitamin D supplement with higher dose than 400 IU in Iranian women is recommended.

Key words

preeclampsia - vitamin D - 25-OH-D - neonates - deficiency - insufficiency
 

  • References

  • 1 American College of Obstetricians and Gynecologists . Hypertension in pregnancy. ACOG Technical Bulletin No. 219. Washington DC. 1996
    Suche in Google Scholar
  • 2 American College of Obstetricians and Gynecologists New Guidelines in Preeclampsia Diagnosis and Care Include Revised Definition of Preeclampsia. Available at https://www.preeclampsia.org/the-news?id=299 Accessed date: December 04, 2013
    PubMed
  • 3 Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis. PLOS One 2014; 9: e91198
    CrossrefPubMedSuche in Google Scholar
  • 4 Zibaeenezhad MJ, Ghodsi M, Arab P, Gholzom N. The prevalence of hypertensive disorders of pregnancy in Shiraz, Southern Iran. Int Cardivasc Res J 2010; 4: 169-172
    PubMedSuche in Google Scholar
  • 5 Vogel JP, Souza JP, Mori R, Morisaki N, Lumbiganon P, Laopaiboon M, Ortiz-Panozo E, Hernandez B, Pérez-Cuevas R, Roy M, Mittal S, Cecatti JG, Tunçalp Ö, Gülmezoglu AM. Maternal complications and perinatal mortality: findings of the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG 2014; 121 (Suppl. 01) 76-88
    CrossrefPubMedSuche in Google Scholar
  • 6 Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; 330: 565
    CrossrefPubMedSuche in Google Scholar
  • 7 Alijahan R, Hazrati S, Mirzarahimi M, Pourfarzi F, AhmadiHadi P. Prevalence and risk factors associated with preterm birth in Ardabil, Iran. Iran J Reprod Med 2014; 12: 47-56
    PubMedSuche in Google Scholar
  • 8 Hajian- Tilaki K, Esmaielzadeh S, Saeghian G. Trend of stillbirth rates and the associated risk factors in Babol, northern Iran. Oman Med J 2014; 29: 18-23
    CrossrefPubMedSuche in Google Scholar
  • 9 Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517-3522
    CrossrefPubMedSuche in Google Scholar
  • 10 Abedi P, Mohaghegh Z, Afshary P, Latifi M. The relationship of serum vitamin D with pre-eclampsia in the Iranian women. Matern Child Nutr 2014; 10: 206-212
    CrossrefPubMedSuche in Google Scholar
  • 11 Xu L, Lee M, Jeyabalan A, Roberts JM. The relationship of hypovitaminosis D and IL-6 in preeclampsia. Am J Obstet Gynecol 2014; 210: 149.e1-149.e7
    CrossrefPubMedSuche in Google Scholar
  • 12 Hebbar S, Misha M, Rai L. Significance of maternal and cord blood nucleated red blood cell count in pregnancies complicated by preeclampsia. J Pregnancy 2014; 496416
    PubMedSuche in Google Scholar
  • 13 Harvey NCW, Javaid MK, Taylor P, Crozier SR, Gale CR, Dennison EM, Cooper C. Umbilical cord calcium and maternal vitamin D status predict different lumbar spine bone parameters in the offspring at 9 years. [abstract]. J Bone Min Res 2004; 19: 1032
    PubMedSuche in Google Scholar
  • 14 Harvey NC, Javaid MK, Poole JR, Taylor P, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Dennison EM. Paternal skeletal size predicts intrauterine bone mineral accrual. J Clin Endocrinol Metab 2008; 93: 1676-1681
    CrossrefPubMedSuche in Google Scholar
  • 15 Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930
    CrossrefPubMedSuche in Google Scholar
  • 16 Ullah MI, Koch CA, Tamanna S, Rouf S, Shamsuddin L. Vitamin D deficiency and the risk of preeclampsia and eclampsia in Bangladesh. Horm Metab Res 2013; 45: 682-687
    Thieme ConnectPubMedSuche in Google Scholar
  • 17 Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of vitamin D deficiency among women and their newborns in an Iranian population.. J Women Health 2009; 18: 835-839
    CrossrefPubMedSuche in Google Scholar
  • 18 Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaillzadeh A. Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J Clin Endocrinol Metab 2013; 98: 3165-3173
    CrossrefPubMedSuche in Google Scholar
  • 19 Gernand AD, Simhan HN, Caritis S, Bodnar LM. Maternal vitamin D status and small-for-gestational-age offspring in women at high risk for preeclampsia. Obstet Gynecol 2014; 123: 40-48
    CrossrefPubMedSuche in Google Scholar
  • 20 Baker AM, Haeri S, Camargo Jr CA, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab 2010; 95: 5105-5109
    CrossrefPubMedSuche in Google Scholar
  • 21 Haugen M, Brantsater AL, Trogstad L, Alexander J, Roth C, Magnus P, Meltzer HM. Vitamin D Supplementation and Reduced Risk of Preeclampsia in Nulliparous Women. Epidemiology 2009; 20: 72-26
    PubMedSuche in Google Scholar