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Horm Metab Res 2016; 48(01): 42-47
DOI: 10.1055/s-0035-1554688
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Body Composition and Epicardial Fat in Type 2 Diabetes Patients Following Insulin Detemir Versus Insulin Glargine Initiation

B. Elisha   *
1   Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
2   Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
,
M. Azar   *
2   Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
3   Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
,
N. Taleb
2   Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
3   Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
,
S. Bernard
2   Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
3   Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
4   Endrocrinology Division, Centre Hospitalier Universitaire de l’université de Montréal (CHUM Hotel-Dieu), Montreal, Quebec, Canada
,
G. Iacobellis
5   Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
,
R. Rabasa-Lhoret
1   Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
2   Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
3   Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
4   Endrocrinology Division, Centre Hospitalier Universitaire de l’université de Montréal (CHUM Hotel-Dieu), Montreal, Quebec, Canada
› Author Affiliations
Further Information

Publication History

received 30 October 2014

accepted 20 May 2015

Publication Date:
04 September 2015 (online)

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Abstract

The aim of the study was to compare body composition and epicardial fat thickness changes in insulin-naïve inadequately controlled patients with type 2 diabetes following basal insulin initiation with detemir vs. glargine. Six-month, open-label, interventional randomized pilot study was conducted. Dual-energy X-ray absorptiometry and echocardiography were used to estimate the body composition and epicardial fat thickness respectively. Thirty-six patients in the detemir group and 20 in the glargine group completed the study. Study groups baseline characteristics were comparable. At 6 months, for similar glycemic control, those on detemir significantly gained less total weight (0.6±2.5 vs. 4.2±4.1 kg, p=0.004), total fat mass (0.9±2.2 vs. 2.9±2.4 kg, p=0.02), and truncal fat mass (0.8±1.5 vs. 2.1±1.7 kg, p=0.02), with a loss in truncal lean mass (− 0.8±1.9 kg vs. 0.3±1.7 kg; p=0.02). EFT significantly decreased from baseline in both group (detemir − 1.7±0.52−mm, glargine − 1.1±1.6−mm; p<0.05, without significant difference inter-groups). Within the detemir group, epicardial fat thickness change correlated with truncal fat and total fat mass changes (r=0.65, p=0.06 and r=0.60, p=0.07). In conclusion, detemir resulted in less fat mass gain, a trend for a more pronounced epicardial fat thickness reduction when compared with glargine.

Key words

insulin analogues - total body weight - truncal fat mass

* Equal 1st co-authorship


Supporting Information

 

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