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Synthesis 2015; 47(23): 3701-3710
DOI: 10.1055/s-0035-1560208
DOI: 10.1055/s-0035-1560208
paper
New and Efficient Synthesis of 2,3,4-Trisubstituted 2H-Pyrrolo[3,4-c]quinolines via a MCR/Staudinger/Aza-Wittig Sequence
Further Information
Publication History
Received: 07 July 2015
Accepted after revision: 14 August 2015
Publication Date:
01 September 2015 (online)
Abstract
A new and efficient method for the construction of 2,3,4-trisubstituted 2H-pyrrolo[3,4-c]quinoline derivatives was developed. Starting from easily accessible 2-azidobenzaldehyde, nitromethane, 1,3-dicarbonyl compounds, and various amines gave the multicomponent reaction (MCR) products, 1-substituted 3-acyl-4-(2-azidophenyl)-2-methyl-1H-pyrroles, that underwent Staudinger/aza-Wittig cyclization of in the presence of triphenylphosphine to give the final products.
Key words
2H-pyrrolo[3,4-c]quinolones - multicomponent reaction - azide - aza-Wittig reaction - iminophosphoraneSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560208.
- Supporting Information
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Reports for the synthesis of pyrrolo[3,4-c]quinolines