Synthesis 2016; 48(17): 2816-2822
DOI: 10.1055/s-0035-1560439
special topic
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Reductive Carboxylation of Cyclopropyl Motifs with Carbon Dioxide

Toni Moragas
a   Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Catalonia, Spain
,
Ruben Martin*
a   Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Catalonia, Spain
b   Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys 23, 08010 Barcelona, Catalonia, Spain   Email: rmartinromo@iciq.es
› Author Affiliations
Further Information

Publication History

Received: 09 March 2016

Accepted: 13 March 2016

Publication Date:
11 April 2016 (online)


Abstract

A nickel-catalyzed reductive carboxylation technique for the synthesis of cyclopropanecarboxylic acids has been developed. This user-friendly and mild transformation operates at atmospheric pressure of carbon dioxide and utilizes either organic halides or alkene precursors, thus representing the first example of catalytic reductive carboxylation of secondary counterparts lacking adjacent π-components.

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Primary Data