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Synthesis 2016; 48(23): 4060-4071
DOI: 10.1055/s-0035-1560557
DOI: 10.1055/s-0035-1560557
short review
Synthesis and Applications of Fluorocyclopropanes
Further Information
Publication History
Received: 22 June 2016
Accepted after revision: 02 July 2016
Publication Date:
16 August 2016 (online)
Abstract
The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant scaffolds with potential interest for the synthesis of new bioactive compounds. In this review, we report the impressive progress recently devoted to the synthesis of fluorocyclopropanes especially using asymmetric methods and highlight some recent reported applications.
1 Introduction
2 Addition of Carbenes to Fluoroalkenes
3 Addition of Fluorocarbenes to Alkenes
4 Michael Initiated Ring Closure
5 Nucleophilic Fluorination
6 Applications to the Synthesis of Biorelevant Compounds
7 Conclusion
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