Asymmetric Iterative Hydration of Polyene Strategy to Cryptocaryols A and B

Abstract

The development of two iterative asymmetric hydration approaches to the synthesis of all syn- and syn/anti/syn-1,3,5,7-tetraol motifs is described. These pseudo-symmetric products are synthetic precursors for 1,3-hexol products. The utility of the route to the all syn-1,3,5,7-tetraol diastereoisomer was demonstrated with its use in the synthesis of cryptocaryols A and B, as well as, stereoisomers.

Key words

asymmetric synthesis - iterative hydration - cryptocaryol A - cryptocaryol B - 1,3-polyols

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