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Synthesis 2016; 48(20): 3470-3478
DOI: 10.1055/s-0035-1562466
DOI: 10.1055/s-0035-1562466
short review
Metal-Catalyzed Cyclizations to Pyran and Oxazine Derivatives
Further Information
Publication History
Received: 03 June 2016
Accepted: 06 June 2016
Publication Date:
26 July 2016 (online)
Abstract
Pyrans are privileged heterocyclic structures found in numerous natural compounds with extraordinary biological activities. The synthesis of these relevant structures has attracted a great deal of attention over the years. Catalytic methodologies based on the activation of neutral unsaturated functionalities of acyclic compounds that undergo intramolecular cyclizations have achieved prominent synthetic relevance. In this short review, we discuss the successful construction of dihydropyran and dihydro-1,4-oxazine derivatives from acyclic precursors by metal-catalyzed intramolecular cyclizations through carbon–carbon, carbon–oxygen, and carbon–nitrogen bond formation. Remarkable synthetic applications are highlighted.
1 Introduction
2 3,4-Dihydropyrans
3 3,4-Dihydro-1,4-oxazines
4 3,6-Dihydropyrans
5 Synthetic Applications
6 Summary
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