Neuropediatrics 2015; 46(05): 344-351
DOI: 10.1055/s-0035-1563533
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Brain Perfusion Is Increased at Term in the White Matter of Very Preterm Newborns and Newborns with Congenital Heart Disease: Does this Reflect Activated Angiogenesis?

Pia Wintermark
1   Department of Pediatrics, McGill University, Montreal, Canada
2   Department of Radiology, Boston Children's Hospital, Boston, United States
,
Mirna Lechpammer
3   Department of Pathology, University of California Davis Medical Center, Sacramento, United States
4   Department of Pathology, Boston Children's Hospital, Boston, United States
5   Department of Neurology, Boston Children's Hospital, Boston, United States
,
Bela Kosaras
5   Department of Neurology, Boston Children's Hospital, Boston, United States
,
Frances E. Jensen
5   Department of Neurology, Boston Children's Hospital, Boston, United States
6   Department of Neurology, University of Pennsylvania, Philadelphia, United States
,
Simon K. Warfield
2   Department of Radiology, Boston Children's Hospital, Boston, United States
› Author Affiliations
Further Information

Publication History

14 April 2015

04 July 2015

Publication Date:
04 September 2015 (online)

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Abstract

Objective This study aims to evaluate brain perfusion at term in very preterm newborns and newborns with congenital heart disease before their corrective surgery, and to search for histopathological indicators of whether the brain perfusion abnormalities of these newborns may be related to an activated angiogenesis.

Materials and Methods Using magnetic resonance imaging and arterial spin labeling, regional cerebral blood flow was measured at a term-equivalent age for three very preterm newborns (born at < 32 weeks), one newborn with congenital heart disease before his corrective surgery and three healthy newborns. In addition, a histopathological analysis was performed on a newborn with congenital heart disease.

Results The very preterm newborns and the newborn with congenital heart disease included in this study all displayed an increased signal in their white matter on T2-weighted imaging. The cerebral blood flow of these newborns was increased in their white matter, compared with the healthy term newborns. The vascular endothelial growth factor was overexpressed in the injured white matter of the newborn with congenital heart disease.

Conclusion Brain perfusion may be increased at term in the white matter, in very preterm newborns, and newborns with congenital heart disease, and it correlates with white matter abnormalities on conventional imaging.