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Synthesis 2017; 49(09): 2081-2087
DOI: 10.1055/s-0036-1588385
DOI: 10.1055/s-0036-1588385
paper
Enamine-Mediated 1,3-Dipolar Cycloaddition Reaction of Curcumin Derivatives with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles
Further Information
Publication History
Received: 25 October 2016
Accepted after revision: 06 December 2016
Publication Date:
12 January 2017 (online)
Abstract
An enamine-mediated [3+2] organocatalytic 1,3-dipolar cycloaddition reaction of curcumin derivatives with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities under mild conditions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588385.
- Supporting Information
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For selected examples of 1,2,3-triazole synthesis, see: