Copper-Catalyzed Intramolecular C–H Amination: A New Entry to Substituted Xanthine Derivatives

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

Catalytic synthesis of xanthines was achieved in the presence of a copper catalyst. The process involves copper-catalyzed intramolecular C–H amination of benzamidines that possess a uracil moiety and produces variously substituted xanthines generally in good to high yields. This work introduces a new, facile approach to polysubstituted xanthine compounds.

Key words

copper - catalysis - C–H functionalization - amination - cyclization­ - xanthines

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