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Synthesis 2018; 50(07): 1527-1534
DOI: 10.1055/s-0036-1589166
DOI: 10.1055/s-0036-1589166
paper
A Highly Efficient CuCl2-Catalyzed C–S Coupling of Aryl Iodides with Tetraalkylthiuram Disulfides: Synthesis of Aryl Dithiocarbamates
National Natural Science Foundation of China (21302150), Hubei Provincial Department of Education (D20131501), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2012]1707, foundation of Chutian distinguished fellow from Hubei Provincial Department of Education, foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology. Z.-B. D. acknowledges the Humboldt Foundation and China Scholarship Council for a fellowship.
Further Information
Publication History
Received: 21 November 2017
Accepted after revision: 10 December 2017
Publication Date:
11 January 2018 (online)
‡ These authors contributed equally to this work
Abstract
A highly efficient copper(II)-catalyzed C–S cross-coupling reaction of aryl iodides with tetraalkylthiuram disulfides was developed. With only 1 mol% of CuCl2 as catalyst, zinc powder as reductant, and K2CO3 as base, aryl iodides reacted with tetraalkylthiuram disulfides in DMSO furnishing the corresponding aryl dithiocarbamates in good to excellent yields. This protocol is an improvement of previous work, it features convenient performance, low addition of catalyst, no requirement for any ligand, and provides good yields. The method has a broad substrate scope and uses cheap and readily available starting materials.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589166.
- Supporting Information
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