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Synthesis 2017; 49(21): 4808-4826
DOI: 10.1055/s-0036-1590878
DOI: 10.1055/s-0036-1590878
short review
The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization
This work was partially supported by INSA Rouen, Rouen University, CNRS, EFRD, Labex SynOrg (ANR-11-LABX-0029) and Région Normandie (Crunch Network). Q. Z. thanks the CSC (China Scholarship Council) for a doctoral fellowship.Further Information
Publication History
Received: 12 July 2017
Accepted: 14 July 2017
Publication Date:
23 August 2017 (online)
Abstract
In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.
1 Introduction
2 From a Historical Point of View
3 Functionalization of Carbonyl Derivatives
4 Functionalization of Amines Derivatives
5 Summary and Outlook
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For selected recent reviews and accounts, see:
For selected examples, see:
For selected reviews regarding meta and para functionalization, see:
For selected examples of functionalization at the meta or para positions, see:
For selected accounts for remote C–H activation:
For selected examples on remote C–H bond functionalization on C(sp3) centers, see:
For selected examples, see:
For an account, see:
For selected examples, see:
For selected reviews, see:
For selected examples, see:
For recent reviews, see: