Friedel–Crafts Alkylation of Aromatics by TiCl₄-Promoted Ring Cleavage of 3-Arylcyclobutanones

Dedicated to Professor Teruaki Mukaiyama in celebration of his 90^th birthday

Abstract

Ring cleavage of 3-arylcyclobutanones and successive Friedel–Crafts alkylation of methoxy- or alkyl-substituted benzene derivatives proceeded to give 3,3-diarylbutan-2-ones by activation with titanium tetrachloride.

Key words

cyclobutanone - Friedel–Crafts alkylation - ring cleavage - Lewis acid - aromatics

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