Direct Oxytosylation of 8-Amidoquinolines by Koser’s Reagent: An Efficient Strategy for 5-Substituted 8-Amidoquinolines

Abstract

A metal-free remote oxytosylation of 8-amidoquinolines has been achieved using Koser’s reagent to produce 5-tosyloxy-8-amidoquinolines in good yields. This method is compatible with various functional groups present on the aromatic ring.

Key words

Koser’s reagent - C–H activation - 8-amidoquinolines - oxytosylation - hypervalent iodine reagents

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