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Synthesis 2019; 51(18): 3511-3519
DOI: 10.1055/s-0037-1611888
DOI: 10.1055/s-0037-1611888
paper
KI-Promoted Oxidative Coupling of Styrenes with Indoles under Metal-Free Conditions: Facile Access to C-3 Dicarbonyl Indoles
This research was supported by the National Key Research and Development Program of China (2016YFB0301501), the National Natural Science Foundation of China (Grant Nos. 21776130 & 21878145), the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (Nos. X1821 & X1802), the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP), and the Postgraduate Research & Practice Innovation Program of Jiangsu Province.Further Information
Publication History
Received: 13 May 2019
Accepted after revision: 21 June 2019
Publication Date:
11 July 2019 (online)
Abstract
A new and efficient method for the synthesis of C-3 dicarbonyl indoles via oxidative cross-coupling of styrenes with indoles under metal-free conditions has been developed. Moreover, a broad scope of C-3 dicarbonyl indoles in moderate to good yields were obtained, and a plausible mechanism is proposed based on control and isotope-labeling experiments.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611888.
- Supporting Information
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