Halonium-Induced Polyene Cyclizations

^‡ These authors contributed equally

Abstract

This review covers the methods that chemists have developed to access halogenated polycyclic structures from polyenes, by emulating Nature’s enzymatic machineries. From pioneering studies to the most recent developments, the different strategies, whether based on the use of standard reagents or on the design of specific ones, will be presented. Finally, asymmetric reactions and applications for the total synthesis of natural products will be exposed.

1 Introduction

2 Pioneering Studies

3 Use of Specific Reagents

4 Use of N-Haloamides

5 Asymmetric Reactions

6 Total Synthesis of Halogenated Natural Products

7 Conclusion and Perspectives

Key words

halogenation - polyenes - biomimetic synthesis - cascade cyclization­ - asymmetric synthesis - natural products

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