Thromb Haemost 2002; 87(01): 105-109
DOI: 10.1055/s-0037-1612951
Review Article
Schattauer GmbH

Tissue-type Plasminogen Activator –7,351C/T Enhancer Polymorphism Is Associated with a First Myocardial Infarction

Per Ladenvall*
1   Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Östra, Göteborg University, Göteborg
,
Lars Johansson*
2   Department of Medicine-Geriatric, Skellefteå County Hospital, Department of Public Health and Clinical Medicine, Umeå University, Umeå
,
Jan-Håkan Jansson
2   Department of Medicine-Geriatric, Skellefteå County Hospital, Department of Public Health and Clinical Medicine, Umeå University, Umeå
3   The Medical Biobank, Umeå University, Umeå
,
Sverker Jern
1   Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Östra, Göteborg University, Göteborg
,
Torbjörn K. Nilsson
4   Department of Clinical Chemistry, Umeå University Hospital, Umeå University, Umeå, Sweden
,
Anna Tjärnlund
1   Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Östra, Göteborg University, Göteborg
,
Christina Jern
1   Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Östra, Göteborg University, Göteborg
,
Kurt Boman
2   Department of Medicine-Geriatric, Skellefteå County Hospital, Department of Public Health and Clinical Medicine, Umeå University, Umeå
3   The Medical Biobank, Umeå University, Umeå
› Author Affiliations
Further Information

Publication History

Received 09 April 2001

Accepted after resubmission 24 September 2001

Publication Date:
13 December 2017 (online)

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Summary

We recently identified a polymorphic Sp1 binding site in an enhancer at the tissue-type plasminogen activator (tPA) locus (tPA –7,351C/T), which was associated with vascular tPA release. Subjects homozygous for the –7,351C allele had twice the tPA release rate compared to subjects carrying the –7,351T allele. In this study we tested the hypothesis that the tPA –7,351C/T polymorphism is associated with myocardial infarction (MI). In a population-based prospective nested case-control study within northern Sweden, genotypes were determined among 61 MI cases and 120 controls. In a multivariate model, the tPA –7,351C/T polymorphism (OR 2.68 for T allele carriers; 95% CI 1.31– 5.50), tPA antigen (OR 1.16; 95% CI 1.07–1.25) and apo A-I (OR, 0.997; 95% CI 0.995–0.999) were independently associated with a first MI. These findings suggest that genetic markers of local tPA release and circulating steady-state tPA levels carry independent prognostic information.

* Both authors contributed equally to this work