Influence of the nt 2148 A to G Substitution (Pro 626 Dimorphism) in the PROS1 Gene on Circulating Free Protein S Levels in Healthy Volunteers - Reappraisal of Protein S Normal Ranges

C. Leroy-Matheron; J. Duchemin; M. Levent; M. Gouault-Heilmann

doi:10.1055/s-0037-1613919

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 83(05): 798-799
DOI: 10.1055/s-0037-1613919

Letters to the Editor

Schattauer GmbH

Influence of the nt 2148 A to G Substitution (Pro 626 Dimorphism) in the PROS1 Gene on Circulating Free Protein S Levels in Healthy Volunteers - Reappraisal of Protein S Normal Ranges

Authors

C. Leroy-Matheron

¹From Unité d’Hémostase et de Thrombose, Centre Hospitalier et Universitaire Henri Mondor, Créteil, France
J. Duchemin

¹From Unité d’Hémostase et de Thrombose, Centre Hospitalier et Universitaire Henri Mondor, Créteil, France
M. Levent

¹From Unité d’Hémostase et de Thrombose, Centre Hospitalier et Universitaire Henri Mondor, Créteil, France
M. Gouault-Heilmann

¹From Unité d’Hémostase et de Thrombose, Centre Hospitalier et Universitaire Henri Mondor, Créteil, France

Abstract

Full Text

References

References
1 Leroy-Matheron C, Duchemin J, Levent M, Gouault-Heilmann M. Genetic modulation of plasma protein S levels by two frequent dimorphisms in the PROS1 gene. Thromb Haemost 1999; 82: 1088-92.
2 Bertina RM. Prevalence of hereditary thrombophilia and the identification of the genetic risk factors. Fibrinolysis 1988; 02: 7-13.
3 Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 1988; 59: 18-22.
4 Faioni EM, Valsecchi C, Palla A, Taioli E, Razzari C, Mannucci PM. Free protein S deficiency is a risk factor for venous thrombosis. Thromb Haemost 1997; 78: 1343-6.
5 Gari M, Kalkon L, Urrutia T, Valvé C, Borrell M, Fontcuberta J. The influence of low protein S plasma levels in young women on the definition of normal range. Thromb Res 1995; 73: 149-52.
6 Henkens CMA, Bom VJJ, van der Schaaf W, Pelsma PM, Smit Sibinga CT, de Kam PJ, van der Meer J. Plasma levels of protein S, protein C, and factor X: effects of sex, hormonal state and age. Thromb Haemost 1995; 74: 1271-5.
7 Griffin JH, Gruber A, Fernandez JA. Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudine. Blood 1992; 79: 3203-11.
8 Garcia de Frutos P, Alim RIM, Härdig Y, Zöller B, Dahlbäck B. Differential regulation of α and β chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S. Blood 1994; 84: 815-22.
9 Zöller B, Garcia de Frutos P, Dahlbäck B. Evaluation of the relationship between protein S and C4b-binding protein isoforms in hereditary protein S deficiency demonstrating type I and type III deficiencies to be phenotypic variants of the same genetic disease. Blood 1995; 85: 3524-31.
10 Simmonds RE, Zöller B, Ireland H, Thompson E, Garcia de Frutos P, Dahlbäck B, Lane DA. Genetic and phenotypic analysis of a large (122 members) protein S-deficient kindred provides an explanation for the familial coexistence of type I and type III plasma phenotypes. Blood 1997; 89: 4364-70.
11 Hermida J, Faioni EM, Mannucci PM. Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene. Thromb Haemost 1999; 82: 1634-8.
12 Carr Jr ME, Steingold KA, Zekert SL. Protein S levels during the normal menstrual cycle and during estrogen therapy for premature ovarian failure. Am J Med Sci 1993; 306: 212-7.
13 Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood 1986; 68: 881-5.
14 Malm J, Laurell M, Dahlbäck B. Changes in the plasma levels of vitamin K-dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception. B J Haematol 1988; 68: 437-43.