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Thromb Haemost 1998; 79(01): 69-73
DOI: 10.1055/s-0037-1614222
Review Article
Schattauer GmbH

Factor V Q506 Mutation (Activated Protein C Resistance) Associated with Reduced Intrapartum Blood Loss – a Possible Evolutionary Selection Mechanism

Pelle G. Lindqvist
1   The Department of Obstetrics and Gynaecology, University of Lund, University Hospital, Malmö, Sweden
,
Peter J. Svensson
2   The Department of Clinical Chemistry and Coagulation Research, University of Lund, University Hospital, Malmö, Sweden
,
Björn Dahlbäck
2   The Department of Clinical Chemistry and Coagulation Research, University of Lund, University Hospital, Malmö, Sweden
,
Karel Maršál
1   The Department of Obstetrics and Gynaecology, University of Lund, University Hospital, Malmö, Sweden
› Author Affiliations
Further Information

Publication History

Received 27 November 1996

Accepted after resubmission 10 September 1997

Publication Date:
08 December 2017 (online)

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Summary

Objectives. To ascertain whether relationship exists between the presence of APC resistance [a hypercoagulable state due to a mutation (R506Q) in the factor V gene] and the occurrence of pre-eclampsia (PE), intrauterine growth retardation (IUGR), and pregnancy bleeding complications. Design. A retrospective study. Subjects. A study group of 122 women with PE and/or IUGR during a recent pregnancy and a control group of 465 healthy pregnant women. Results. A significantly reduced risk of intrapartum bleeding complications in the APC-resistant subgroup as compared to the non-APC-resistant subgroup was suggested by reduced intrapartum blood loss, and pre- and postpartum haemoglobin measurements. The prevalence of APC resistance in the PE and IUGR subgroups did not differ significantly from that in the control group. Conclusion. The remarkably high prevalence of the potentially harmful factor V gene mutation in the general population may be the result of an evolutionary selection mechanism conferring such survival advantages as reduction in the risk of intrapartum bleeding on carriers of the FV:Q506 allele.

 

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