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Thromb Haemost 2001; 86(01): 124-129
DOI: 10.1055/s-0037-1616208
Research Article
Schattauer GmbH

Protease Crosstalk with Integrins: the Urokinase Receptor Paradigm

Harold A. Chapman
1   Pulmonary and Critical Care Division, University of California at San Francisco, San Francisco, CA, USA
,
Ying Wei
1   Pulmonary and Critical Care Division, University of California at San Francisco, San Francisco, CA, USA
› Author Affiliations
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Publication History

Publication Date:
12 December 2017 (online)

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Summary

Migratory cells use both adhesion receptors and proteolytic enzymes to regulate their interaction with and response to extracellular matrices. Cooperation between integrins and proteases operates at several levels: integrin signaling induces proteases, proteases co-localize with integrins, and proteases regulate the interface between integrins and the intracellular cytoskeleton. One protease system intimately connected to integrins is the urokinase/urokinase receptor(uPAR)/plasmin system. Recent studies indicate urokinase promotes the ligand-like binding of its receptor to a set of β1 and β2 integrins, this binding in turn affecting integrin signaling and cell migration. The glycolipid anchor of uPAR associates with cholesterol-rich membrane rafts. Binding of uPAR to integrins may enrich integrin clusters with signaling molecules such as src-family kinases that localize to rafts and are important to integrin function. Signals derived from integrin/uPAR complexes promote the function of other integrins. Thus the urokinase/plasmin system coordinates with integrins to regulate cell: matrix interactions.

Key words

Urokinase - integrin - signaling - receptor
 

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