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Nuklearmedizin 1994; 33(04): 144-149
DOI: 10.1055/s-0038-1629809
Original Article
Schattauer GmbH

18FDG-PET bei intrakraniellen Meningeomen versus Grading, Proliferationsindex, Zelldichte und zytogenetische Analyse[*]

18FDG-PET in Intracranial Meningiomas versus Grading, Proliferation Index, Cellular Density and Cytogenetical Analysis
U. Cremerius
1   Aus den Kliniken für Nuklearmedizin und Homburg/Saar, FRG
,
E. Striepecke
4   Aus den Kliniken für Pathologie und Homburg/Saar, FRG
,
W. Henn
6   Aus den Kliniken für Humangenetik der Universität des Saarlandes, Homburg/Saar, FRG
,
J. Weis
5   Aus den Kliniken für Neuropathologie der RWTH Aachen und dem Institut für Homburg/Saar, FRG
,
M. Mull
3   Aus den Kliniken für Neuro-radiologie, den Instituten für Homburg/Saar, FRG
,
B. Lippitz
2   Aus den Kliniken für Neurochirurgie, der Abteilung für Homburg/Saar, FRG
,
J. Gilsbach
2   Aus den Kliniken für Neurochirurgie, der Abteilung für Homburg/Saar, FRG
,
J. M. Schröder
5   Aus den Kliniken für Neuropathologie der RWTH Aachen und dem Institut für Homburg/Saar, FRG
,
K. D. Zang
6   Aus den Kliniken für Humangenetik der Universität des Saarlandes, Homburg/Saar, FRG
,
A. Böcking
4   Aus den Kliniken für Pathologie und Homburg/Saar, FRG
,
U. Büll
1   Aus den Kliniken für Nuklearmedizin und Homburg/Saar, FRG
› Author Affiliations
Further Information

Publication History

Eingegangen: 20 January 1994

in revidierter Form: 04 March 1994

Publication Date:
05 February 2018 (online)

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Zusammenfassung

62 intrakranielle Meningeome von 60 Patienten wurden präoperativ durch 18FDG-PET untersucht, um den Zusammenhang zwischen 18FDG-Aufnahme und biologischem Tumorverhalten zu überprüfen. Als Parameter der Tumoraggressivität dienten histopathologisches Grading, Zelldichte, Ki-67-Proliferationsindex und Nachweis chromosomaler Aberrationen. Wir fanden einen signifikant erhöhten 18FDG-Uptake bei Grad 2- und 3- im Vergleich zu Grad 1-Meningeomen, bei zellreichen gegenüber mäßig zellreichen Meningeomen, und bei Tumoren mit einem erhöhten Ki-67-Proliferationsindex (über 2%). Die beiden Meningeome, bei denen die ausgeprägtesten chromosomalen Aberrationen beobachtet wurden, wiesen den höchsten 18FDG-Uptake unter den zytogenetisch untersuchten Meningeomen auf. Hieraus folgern wir, daß die 18FDG-PET zur Abschätzung der biologischen Aggressivität von intrakraniellen Meningeomen geeignet ist.

Summary

62 intracranial meningiomas in 60 patients were studied with 18FDG-PET prior to neurosurgery in order to evaluate the relationship between 18FDG uptake and biological aggressiveness of the tumors. Histopathological grading, cellular density, Ki-67 proliferation index and evidence of chromosomal aberrations were used to assess tumor aggressiveness. Significantly elevated 18FDG uptake was found in grade 2- and 3- compared to grade 1-meningiomas, in tumors of high cellularity compared with those of low cellularity, and in meningiomas with an elevated Ki-67 proliferation index (above 2%). The two meningiomas with the most pronounced chromosomal aberrations revealed the highest 18FDG uptake of all cytogenetically studied meningiomas. We conclude that 18FDG-PET is useful for estimating the biological aggressiveness of intracranial meningiomas.

Schlüsselwörter

Meningeom - Positronen-Emissions-Tomographie - Grading - chromosomale Aberration

Key words

Meningioma - positron emission tomography - grading - chromosomal aberration

* Herrn Prof. Dr. med. D. Emrich zum 65. Geburtstag


 

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