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Thromb Haemost 1994; 71(04): 424-427
DOI: 10.1055/s-0038-1642454
Review Article
Schattauer GmbH Stuttgart

Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

Masahide Yamazaki
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
2   The department of Internal Medicine, Tsuruga City Hospital, Tsuruga, Japan
,
Hidesaku Asakura
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Hiroshi Jokaji
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Masanori Saito
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Chika Uotani
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Ichiro Kumabashiri
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Eriko Morishita
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Keiji Aoshima
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
,
Takayuki Ikeda
2   The department of Internal Medicine, Tsuruga City Hospital, Tsuruga, Japan
,
Tamotsu Matsuda
1   The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
› Author Affiliations
Further Information

Publication History

Received: 10 August 1993

Accepted after resubmission: 30 November 1993

Publication Date:
06 July 2018 (online)

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Summary

The mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

 

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