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Thromb Haemost 1988; 59(02): 277-280
DOI: 10.1055/s-0038-1642770
Original Articles
Schattauer GmbH Stuttgart

Congenital Deficiency of Plasminogen and Its Relationship to Venous Thrombosis

V Hach-Wunderle
1   The Department of Internal Medicine, University Hospital, Frankfurt/Main, FRG
,
I Scharrer
1   The Department of Internal Medicine, University Hospital, Frankfurt/Main, FRG
,
R Lottenberg
2   The Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA
› Author Affiliations
Further Information

Publication History

Received 16 June 1987

Accepted after revision 21 December 1987

Publication Date:
21 May 2018 (online)

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Summary

In a patient with deep venous thrombosis, plasma concentrations of coagulant and inhibitor proteins were normal except for moderate deficiency of plasminogen. Family studies revealed a similar deficiency in the mother and sister of the propositus. Evaluation of purified plasminogen demonstrated that it functioned normally. The patient represents our only example of plasminogen deficiency in 435 German individuals evaluated with a history of thromboembolism.

Keywords

Deep vein thrombosis - Deficiency of plasminogen - Hypercoagulability - Hypoplasminogenemia
 

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