Download PDF
Thromb Haemost 1993; 70(01): 172-176
DOI: 10.1055/s-0038-1646183
State-of-the-Art Lecture
Growth Factors
Schattauer GmbH Stuttgart

Neointimal Proliferation: The Role of Basic FGF on Vascular Smooth Muscle Cell Proliferation

Michael A Reidy
Department of Pathology, University of Washington, Seattle, WA 98195, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 McBride W, Lange RA, Hillis LD. Restenosis after successful coronary angioplasty: Pathophysiology and prevention. N Engl J Med 1990; 318: 269-373
    PubMedSearch in Google Scholar
  • 2 Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976; 295: 369-377
    CrossrefPubMedSearch in Google Scholar
  • 3 Davies PF, Reidy MA, Goode TB, Bowyer DE. Scanning electron microscopy in the evaluation of endothelial integrity of the fatty lesion in atherosclerosis. Atherosclerosis 1976; 25: 125-130
    CrossrefPubMedSearch in Google Scholar
  • 4 Faggiotto A, Ross R, Harker L. Studies in hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis 1984; 4: 323-340
    CrossrefPubMedSearch in Google Scholar
  • 5 Fingerle J, Johnson R, Clowes AW, Majesky MW, Reidy MA. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci USA 1989; 86: 8412-8416
    CrossrefPubMedSearch in Google Scholar
  • 6 Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983; 49: 327-333
    PubMedSearch in Google Scholar
  • 7 Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest 1983; 49: 208-215
    PubMedSearch in Google Scholar
  • 8 Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J Biol Chem 1988; 263: 6579-6587
    PubMedSearch in Google Scholar
  • 9 Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC. Human basic fibroblast growth factor: Nucleotide sequence and genomic organization. EMBO J 1986; 5: 2523-2528
    PubMedSearch in Google Scholar
  • 10 Gospodarowicz D, Neufeld G, Schweigerer L. Fibroblast growth factor: Structural and biological properties. J Cell Physiol 1987; 5 (Suppl) 15-26
    PubMedSearch in Google Scholar
  • 11 Gospodarowicz D, Neufeld G, Schweigerer L. Fibroblast growth factor. Molec Cell Endocrinol 1986; 46: 187-204
    CrossrefPubMedSearch in Google Scholar
  • 12 Edelman ER, Nugent MA, Smith LT, Karnovsky MJ. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J Clin Invest 1992; 89: 465-473
    CrossrefPubMedSearch in Google Scholar
  • 13 Sato Y, Hamanaka R, Ono J, Kuwano M, Rifkin DB, Takaki R. The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF. Biochem Biophys Res Commun 1991; 174: 1260-1266
    CrossrefPubMedSearch in Google Scholar
  • 14 Muthukrishnan L, Warder E, McNeil PL. Basic fibroblast growth factor is efficiently released from a cytosolic storage site through plasma membrane disruptions of endothelial cells. J Cell Physiol 1991; 148: 1-16
    CrossrefPubMedSearch in Google Scholar
  • 15 Klagsbrun M, Edelman ER. Biological and biochemical properties of fibroblast growth factors: Implications for the pathogenesis of atherosclerosis. Arteriosclerosis 1989; 9: 269-278
    CrossrefPubMedSearch in Google Scholar
  • 16 Olson NE, Chao S, Lindner V, Reidy MA. Intimal smooth muscle cell proliferation after balloon catheter injury: The role of basic fibroblast growth factor. Am J Pathol 1992; 140: 1017-1023
    PubMedSearch in Google Scholar
  • 17 Lindner V, Lappi DA, Baird A, Majack RA, Reidy MA. Role of basic fibroblast growth factor in vascular lesion formation. Circ Res 1991; 68: 106-113
    CrossrefPubMedSearch in Google Scholar
  • 18 Lindner V, Reidy MA. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA 1991; 88: 3739-3743
    CrossrefPubMedSearch in Google Scholar
  • 19 Powell PP, Klagsbrun M. Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus. J Cell Physiol 1991; 148: 202-210
    CrossrefPubMedSearch in Google Scholar
  • 20 Florkiewicz RZ, Baird A, Gonzalez AM. Multiple forms of bFGF: Differential nuclear and cell surface localization. Growth Factors 1991; 4: 265-275
    CrossrefPubMedSearch in Google Scholar
  • 21 Renko M, Quarto N, Morimoto T, Rifkin DB. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J Cell Physiol 1990; 144: 108-114
    CrossrefPubMedSearch in Google Scholar
  • 22 Vlodavsky I, Folkman J, Sullivan R, Fridman R, Ishai-Michaeli R, Sasse J, Klagsbrun M. Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci USA 1987; 84: 2292-2296
    CrossrefPubMedSearch in Google Scholar
  • 23 Lindner V, Olson NE, Clowes AW, Reidy MA. Inhibition of smooth muscle cell proliferation in injured rat arteries: Interaction of heparin with basic fibroblast growth factor. J Clin Invest 1992; 90: 2044-2049
    CrossrefPubMedSearch in Google Scholar
  • 24 Yu QC, McNeil PL. Transient disruptions of aortic endothelial cell plasma membranes. Am J Pathol 1992; 141: 1349-1360
    PubMedSearch in Google Scholar
  • 25 Cuevas P, Gonzalez AM, Carceller F, Baird A. Vascular response to basic fibroblast growth factor when infused onto the normal adventitia or into the injured media of the rat carotid artery. Circ Res 1991; 69: 360-369
    CrossrefPubMedSearch in Google Scholar
  • 26 Majack RA, Majesky MW, Goodman LV. Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-β. J Cell Biol 1990; 111: 239-247
    CrossrefPubMedSearch in Google Scholar
  • 27 Reidy MA, Fingerle J, Lindner V. Factors controlling the development of arterial lesions following injury. Circulation. 1993 (in press)
    PubMedSearch in Google Scholar
  • 28 Reidy MA, Jackson C, Lindner V. Neointimal proliferation: Control of vascular smooth muscle growth. Vasc Med Rev 1992; 3: 156-167
    PubMedSearch in Google Scholar
  • 29 Reidy MA, Fingerle J, Lindner V. Factors controlling the development of arterial lesions after injury. Circulation 1992; 86 (Suppl) 43-46
    PubMedSearch in Google Scholar
  • 30 Ferns GAA, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 1991; 253: 1129-1132
    CrossrefPubMedSearch in Google Scholar
  • 31 Jawien AD, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 1992; 89: 507-511
    CrossrefPubMedSearch in Google Scholar
  • 32 Jackson CL, Reidy MA. Basic fibroblast growth factor: Its role in the control of smooth muscle cell migration. Am J Pathol. 1993 (in press)
    PubMedSearch in Google Scholar
  • 33 Ossowski L, Unkeless JC, Tobia A, Quickly JP, Rifkin DB, Reich E. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses. J Exp Med 1973; 85: 112-126
    PubMedSearch in Google Scholar
  • 34 Pollack R, Risser R, Conlon S, Rifkin DB. Plasminogen activator production accompanies loss of anchorage regulation in transformation of primary rat embryo cells by Simian virus 40. Proc Natl Acad Sci USA 1974; 71: 4792-4796
    CrossrefPubMedSearch in Google Scholar
  • 35 Ossowski L, Reich E. Antibodies to plasminogen activator inhibit human tumor metastasis. Cell 1983; 35: 611-619
    CrossrefPubMedSearch in Google Scholar
  • 36 Clowes AW, Clowes MM, Au YPT, Reidy MA, Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 1990; 67: 61-67
    CrossrefPubMedSearch in Google Scholar
  • 37 Jackson CL, Raines EW, Ross R, Reidy MA. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arteriosclerosis. 1993 (in press)
    PubMedSearch in Google Scholar
  • 38 Hoylaerts M, Lijnen HR, Collen D. Studies on the mechanism of antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 1981; 673: 75-85
    CrossrefPubMedSearch in Google Scholar
  • 39 Takada A, Takada Y. Inhibition by tranexamic acid of the conversion of single-chain tissue plasminogen activator to its two-chain form by plasmin: The presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin. Thromb Res 1989; 55: 717-725
    CrossrefPubMedSearch in Google Scholar