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Thromb Haemost 1979; 41(04): 787-795
DOI: 10.1055/s-0038-1646838
Original Articles
Schattauer GmbH Stuttgart

Abnormalities of Platelet Adenine Nucleotides in Patients with Myeloproliferative Disorders

Junji Nishimura
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan
,
Seiki Okamoto
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan
,
Hiroshi Ibayashi
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan
› Author Affiliations
Further Information

Publication History

Received 14 April 1978

Accepted 12 August 1978

Publication Date:
09 July 2018 (online)

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Summary

Platelet aggregation and adenine nucleotides in platelets have been studied in thirteen patients with myeloproliferative disorders. ADP induced aggregation was abnormal in two patients, but collagen induced aggregation was impaired in 11 patients. The concentrations of ATP and ADP in resting platelets in the patients with abnormal aggregation were significantly less than those in normal subjects. Marked reduction of the amounts of both nucleotides released into plasma was also observed after stimulation of collagen in these patients. Platelets in the patients with normal functions contained almost normal amounts of adenine nucleotides. We discussed the relationship between platelet dysfunction and adenine nucleotides in platelets of myeloproliferative disorders and concluded that platelet dysfunction was mainly attributable to reduction of releasable ADP.

 

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