Inhibition of ADP-Induced Platelet Aggregation by Adenosine Tetraphosphate

Margaret J. Harrison; R Brossmer

doi:10.1055/s-0038-1648053

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1976; 36(02): 388-391
DOI: 10.1055/s-0038-1648053

Original Article

Schattauer GmbH

Inhibition of ADP-Induced Platelet Aggregation by Adenosine Tetraphosphate

Margaret J. Harrison

¹Institut für Biochemie II (Med. Fakultät) der Universität Heidelberg, Im Neuenheimer Feld 328, D-6900 Heidelberg, German Federal Republic

,

R Brossmer

¹Institut für Biochemie II (Med. Fakultät) der Universität Heidelberg, Im Neuenheimer Feld 328, D-6900 Heidelberg, German Federal Republic

› Institutsangaben

Abstract

Summary

In contrast to previous reports, highly purified adenosine tetraphosphate (AP₄) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP₄ on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP₄.

Volltext

Referenzen

References
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