Inhibition of ADP-Induced Platelet Aggregation by Adenosine Tetraphosphate

Summary

In contrast to previous reports, highly purified adenosine tetraphosphate (AP₄) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP₄ on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP₄.

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