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Thromb Haemost 1976; 36(02): 388-391
DOI: 10.1055/s-0038-1648053
Original Article
Schattauer GmbH

Inhibition of ADP-Induced Platelet Aggregation by Adenosine Tetraphosphate

Margaret J. Harrison
1   Institut für Biochemie II (Med. Fakultät) der Universität Heidelberg, Im Neuenheimer Feld 328, D-6900 Heidelberg, German Federal Republic
,
R Brossmer
1   Institut für Biochemie II (Med. Fakultät) der Universität Heidelberg, Im Neuenheimer Feld 328, D-6900 Heidelberg, German Federal Republic
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Further Information

Publication History

Received 20 March 1976

Accepted 25 May 1976

Publication Date:
03 July 2018 (online)

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Summary

In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4.

 

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