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Thromb Haemost 1992; 67(01): 117-120
DOI: 10.1055/s-0038-1648391
Original Articles
Schattauer GmbH Stuttgart

No Evidence for Short-Term Regulation of Plasminogen Activator Inhibitor Activity by Insulin in Man

Helena Vuorinen-Markkola
The Second Department of Medicine, Helsinki University, Helsinki, Finland
,
llpo Puhakainen
The Second Department of Medicine, Helsinki University, Helsinki, Finland
,
Hannele Yki-Järvinen
The Second Department of Medicine, Helsinki University, Helsinki, Finland
› Author Affiliations
Further Information

Publication History

Received 03 May 1991

Accepted after revision 26 July 1991

Publication Date:
02 July 2018 (online)

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Summary

In crossectional studies a positive correlation has been found between circulating insulin, triglycerides and plasminogen activator inhibitor (PAI-1) activity. To directly examine the effect of insulin on PAI-1 activity in vivo, we determined the response of PAI-1 activity in 17 normal subjects to acute hyperinsulinemia (serum free insulin 92 ± 8 mU/l) during maintenance of normoglycemia (plasma glucose 5.1 ± 0.1 mmol/l). In 12 matched control subjects PAI-1 activity was measured during infusion of saline (serum free insulin 3.6 ± 0.3 mU/l, plasma glucose 5.2 ± 0.1 mmol/l). Plasma PAI-1 activity decreased during the insulin infusion from 9.0 α 1.4 to 5.6 α 0.8 U/ml (p <0.01), and during saline infusion from 7.0 ± 1.4 to 4.3 ± 0.6 U/ml (p <0.05). Serum triglyceride concentrations decreased from 1.09 ± 0.20 to 0.76 ± 0.09 mmol/l (p < 0.001) during hyperinsulinemia but remained unchanged during the saline infusion (1.04 ± 0.11 vs. 1.02 ± 0.12 mmol/l, NS). We conclude that insulin does not acutely change plasma PAI-1 activity, and that acute insulin-induced changes in serum triglycerides occur independently from those of PAI-1 activity.

 

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