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Thromb Haemost 1992; 67(02): 189-192
DOI: 10.1055/s-0038-1648410
Original Articles
Schattauer GmbH Stuttgart

Type I Congenital Plasminogen Deficiency Is not a Risk Factor for Thrombosis

T Shigekiyo
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
Y Uno
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
A Tomonari
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
K Satoh
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
H Hondo
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
S Ueda
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
S Saito
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
› Author Affiliations
Further Information

Publication History

Received 09 April 1991

Accepted after revision 21 August 1991

Publication Date:
02 July 2018 (online)

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Summary

The risk of thrombosis in type I congenital plasminogen (PLG) deficiency has been suggested, but is still not confirmed. We studied 40 members of two unrelated families with this disease, and found that 21 were heterozygotes of type I congenital PLG deficiency. Three of them had thrombosis, but the other 18 had no thrombosis. The percentages of family members with no history of thrombosis up to a given age among subjects with type I congenital PLG deficiency and healthy controls were analyzed by the Kaplan-Meier method. No significant difference between the two groups was observed by the generalized Wilcoxon test (p = 0.23). These results suggest that there is no significant correlation between type I congenital PLG deficiency and thrombosis.

 

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