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Thromb Haemost 1993; 70(03): 386-388
DOI: 10.1055/s-0038-1649590
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

Treatment of Severe Venous Thrombo-Embolism with Intravenous Hirudin (HBW 023): An Open Pilot Study

Florence Parent
1   The Department of Pneumology, Université Paris-Sud, Clamart, France
,
Françoise Bridey
2   The Department of Haematology, Université Paris-Sud, Clamart, France
,
Marie Dreyfus
2   The Department of Haematology, Université Paris-Sud, Clamart, France
,
Dominique Musset
3   The Department of Radiology, Université Paris-Sud, Clamart, France
,
Gilles Grimon
4   Department of Nuclear Medicine, Hôpital Antoine Béclère, Université Paris-Sud, Clamart, France
,
Pierre Duroux
1   The Department of Pneumology, Université Paris-Sud, Clamart, France
,
Dominique Meyer
2   The Department of Haematology, Université Paris-Sud, Clamart, France
,
Gérald Simonneau
1   The Department of Pneumology, Université Paris-Sud, Clamart, France
› Author Affiliations
Further Information

Publication History

Received 23 November 1992

Accepted after revision 05 April 1993

Publication Date:
05 July 2018 (online)

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Summary

Recombinant Hirudin (rH) is an anticoagulant agent with a specific antithrombin activity independent of antithrombin III. We report the results of the first open pilot study on the curative treatment of acute venous thrombo-embolism (VTE) with rH (HBW 023) in ten patients. The dose of rH tested was 0.07 mg/kg (i.v. bolus) followed by 0.05 mg kg-1 h-1 (i.v. infusion) for 5 days, without activated partial thromboplastin time (APTT) adjustment. Within the trial, no death, VTE recurrence or major bleeding was observed; lung scan pulmonary vascular obstruction improved from 44 to 37%, whereas the venographic Marder score was unchanged; APTT ratio ranged between 1.2 and 2.8. The dose of rH assessed in this study seems to be safe and efficient in the treatment of acute VTE.

 

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