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Thromb Haemost 1995; 74(06): 1432-1435
DOI: 10.1055/s-0038-1649960
Original Articles
Clinical Studies
Schattauer GmbH Stuttgart

Subcutaneous Low-Molecular-Weight Heparin Fragmin Versus Intravenous Unfractionated Heparin in the Treatment of Acute Non Massive Pulmonary Embolism: An Open Randomized Pilot Study

G Meyer
1   The Service de Pneumologie et Réanimation, Hôpital Laennec, Paris, France
,
F Brenot
2   The Service de Pneumologie et Réanimation, Hôpital Antoine Béclère, Clamart, France
,
G Pacouret
3   The Service de Cardiologie D, Hôpital Trousseau, Tours, France
,
G Simonneau
2   The Service de Pneumologie et Réanimation, Hôpital Antoine Béclère, Clamart, France
,
K Gillet Juvin
1   The Service de Pneumologie et Réanimation, Hôpital Laennec, Paris, France
,
B Charbonnier
3   The Service de Cardiologie D, Hôpital Trousseau, Tours, France
,
H Sors
1   The Service de Pneumologie et Réanimation, Hôpital Laennec, Paris, France
› Institutsangaben
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Publikationsverlauf

Received: 08. Juni 1995

Accepted after revision 12. September 1995

Publikationsdatum:
10. Juli 2018 (online)

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Summary

Low-molecular-weight heparins have been extensively investigated in the treatment of deep venous thrombosis but limited data are available concerning their use in pulmonary embolism. In an open, pilot, randomized study, we compare the safety and efficacy of Fragmin, a low-molecular-weight heparin with those of unfractionated heparin in 60 patients with non massive pulmonary embolism (Miller Index < 20). Thirty one patients received unfractionated heparin intravenously and 29 received a fixed dose of 120 Anti-Xa IU/kg of Fragmin administered subcutaneously twice a day for 10 days. There was no pulmonary embolism recurrence nor major bleeding in either group during the treatment period. The decrease in pulmonary vascular obstruction on perfusion lung scan between day 0 and day 10 was 17 ± 13% in the Fragmin group and 16 ± 13% in the heparin group (NS). These results indicate that Fragmin may be a safe and effective treatment of submassive pulmonary embolism.

 

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