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Thromb Haemost 1996; 75(04): 551-554
DOI: 10.1055/s-0038-1650319
Original Article
Schattauer GmbH Stuttgart

Evaluation of a Soluble Fibrin Assay in Patients with Suspected Pulmonary Embolism

Jeffrey S Ginsberg
The Department of Medicine, McMaster University, Hamilton, Canada
,
Sergio Siragusa
The Department of Medicine, McMaster University, Hamilton, Canada
,
James Douketis
The Department of Medicine, McMaster University, Hamilton, Canada
,
Marilyn Johnston
The Department of Medicine, McMaster University, Hamilton, Canada
,
Karen Moffat
The Department of Medicine, McMaster University, Hamilton, Canada
,
Dianne Donovan
The Department of Medicine, McMaster University, Hamilton, Canada
,
Joanne McGinnis
The Department of Medicine, McMaster University, Hamilton, Canada
,
Patrick Brill-Edwards
The Department of Medicine, McMaster University, Hamilton, Canada
,
Akbar Panju
The Department of Medicine, McMaster University, Hamilton, Canada
,
Ameen Patel
The Department of Medicine, McMaster University, Hamilton, Canada
,
Jeffrey I Weitz
The Department of Medicine, McMaster University, Hamilton, Canada
› Author Affiliations
Further Information

Publication History

Received 07 August 1995

Accepted after resubmission 10 January 1996

Publication Date:
10 July 2018 (online)

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Summary

In order to determine the clinical utility of an enzyme immunoassay (EIA) for soluble fibrin in patients with suspected pulmonary embolism (PE), 195 unselected patients with suspected PE underwent blood sampling for measurement of plasma levels of soluble fibrin, and objective testing for PE. A soluble fibrin result of ≤ 0.75 Μg/ml showed a sensitivity of 100% for PE and a specificity of 12.8%, whereas a soluble fibrin result of ≤ 1.35 Μg/ml showed a sensitivity of 90.3% and a specificity of 49.4% for PE. The soluble fibrin assay has potential clinical utility in excluding PE.

 

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