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Thromb Haemost 1987; 57(03): 372
DOI: 10.1055/s-0038-1651135
DOI: 10.1055/s-0038-1651135
Letters to the Editor
Synergism of Tissue-Type Plasminogen Astivator (t-PA) and Single-Chain Urokinase-Type Plasminogen Activator (scu-PA) on Clot Lysis In Vitro and a Mechanism for this Effect
Authors
Further Information
Publication History
Received 19 December 1986
Accepted after revision 12 February 1987
Publication Date:
06 July 2018 (online)
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References
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- 2 Gurewich V, Pannell R. Clot lysis by pro-urokinase (PUK) and/or t-PA - a comparative study. Thromb Haemostas 1985; 54: 122 (Abstr)
- 3 Berenbaum MC. Synergy, additivism and antagonism in immunosuppression. A critical review. Clin Exp Immunol 1977; 28: 1
- 4 Gurewich V, Pannell R. A comparative study of the efficacy and specificity of tissue plasminogen avtivator and pro-urokinase: demonstration of synergism and of different thresholds of non-selectivity. Thromb Res 1986; 44: 217-228
- 5 Webster’s Seventh New Collegiate Dictionary G and C Merriam Company; 1965. Springfield, MA USA:
- 6 Pannell R, Gurewich V. Pro-urokinase - a study of fits stability in plasma and of a mechanism for its selective fibrinolytic effect. Blood 1986; 67: 1215-1223
- 7 Harpel PC, Chang T-S, Verderber E. Tissue plasminogen activator and urokinase mediate the binding of glu-plasminogen to plasma fibrin I. J Biol Chem 1985; 260: 4432-4440
- 8 Gurewich V, Pannell R, Black J. A mechanism for the potentiating effect of urokinase (UK) or tissue plasminogen activator (t-PA) on clot lysis by prourokinase (pro-UK). XIth Internat’l Congr. Thromb Haemostas. 1987 (Abstr)
- 9 Gurewich V, Pannell R. Fibrinolytic synergism by t-PA and pro-UK and their different thresholds of non-selectivity. Fibrinolysis 1986; 0: 109
- 10 Mohler SR, Celander DR, Guest MM. Distribution of urokinase among common mammals. Am J Physiol 1958; 192: 186-190
- 11 Matsu O, Mihara H. Threshold phenomena in blood fibrinolysis. Thromb Res 1977; 10: 753-758
- 12 Gurewich V, Pannell R, Louie S, Kelley P, Suddith RL, Greenlee R. Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (prourokinase). A study in vitro and in two animal species. J Clin Invest 1984; 73: 1731-1739