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Thromb Haemost 1968; 19(03/04): 346-363
DOI: 10.1055/s-0038-1651213
Originalarbeiten – Original Articles – Travaux Originaux
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Kinetic Aspects of the Interaction of Blood Clotting Enzymes

III. Demonstration of an Inhibitor of Prothrombin Conversion in Vitamin K Deficiency
H. C Hemker
1   Laboratory of Coagulation Biochemistry, Hematology Section, Department of Internal Medicine, University Hospital, Leyden, The Netherlands
,
J. J Veltkamp
1   Laboratory of Coagulation Biochemistry, Hematology Section, Department of Internal Medicine, University Hospital, Leyden, The Netherlands
,
E. A Loeliger
1   Laboratory of Coagulation Biochemistry, Hematology Section, Department of Internal Medicine, University Hospital, Leyden, The Netherlands
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Publication Date:
27 June 2018 (online)

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Summary

Application of enzyme kinetics to the results of thrombotest estimations in correlation with specific clotting factor estimations has led to the recognition of a protein moiety that occurs in plasma in vitamin K deficiency and acts as a competitive inhibitor of thrombin formation. A hypothesis is given by which the occurrence of this inhibitor is explained in terms of a biphasic synthesis of the vitamin K-dependent clotting factors.

 

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