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Thromb Haemost 1977; 38(02): 0399-0406
DOI: 10.1055/s-0038-1651475
Original Article
Schattauer GmbH

Platelet Coagulant Activities and Retinal Vein Thrombosis

Peter N. Walsh
1   Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.
,
Richard E. Goldberg
1   Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.
,
Richard L. Tax
1   Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.
,
Larry E. Magargal
1   Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 10 November 1976

Accepted 10 April 1977

Publication Date:
04 July 2018 (online)

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Summary

To determine whether platelets play a role in the pathogenesis of retinal vein occlusion (RVO), platelets and coagulation were evaluated in 28 patients with RVO. Platelet coagulant activities concerned with the initiation and early stages of intrinsic coagulation were 2–4 fold increased in 9 patients with acute primary RVO but not in patients with acute secondary (10 patients) or chronic (9 patients) RVO. Platelet factor 3 activity, platelet aggregation, serotonin release by platelets and plasma coagulation were normal in all patients. Platelets may provide a trigger mechanism for venous thrombosis in the eye when local conditions permit.

 

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